Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. read more

Intrinsically disordered proteins are abundant in eukaryotic systems, but they remain largely elusive pharmacological targets. NMR spectroscopy proved to be a suitable method to study these proteins. read more

Fluorinated amino acids can be easily incorporated in proteins expressed in human cells, allowing 19F in-cell NMR studies of proteins that would otherwise be invisible by 1H-detected in-cell NMR. read more

Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic efficacy and safety. read more