Associate Professor
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AFFILIATION: ADDRESS: CONTACTS: RESEARCH PROFILES: |
Antonio Rosato, born in 1971, graduated in Chemistry in 1995 (110/110 cum laude), and received his PhD in Chemistry in 1998 at the University of Florence. He has received the "Premio Nazionale Federchimica" in 1996, the Prize "Sapio NMR Junior" in 2001 and the Prizes "Gastone De Santis" and "Raffaello Nasini", both from the Italian Chemical Society, in 2005 and 2009 respectively. Metalloproteins are the main focus of his research activities, mostly in the area of experimental and computational structural biology of these systems. Antonio Rosato has developed innovative methodologies for the study via NMR of the solution structure of paramagnetic metalloproteins, and for the investigation of the determinants of the thermodynamic stability of the fold of these systems through the combination of various biophysical methods. He is actively working on the implementation of bioinformatics research on metalloproteins, including their identification in the genomes, the prediction of their structure and of their interactions of biological relevance, the creation and analysis of a database of metal sites in macromolecular structures. He has been the PI of the Florence unit within various international collaborations funded also by the European Commission (e.g. WeNMR, www.wenmr.eu). These collaborations provide access based on web interfaces to software tools for the analysis of NMR data, using grid / cloud computational infrastructures. Antonio Rosato co-authored about 120 articles in scientific journals of international renown and book chapters. He has contributed to the determination of the structure in solution of around thirty metalloproteins. His H-index is 42 (ISI) / 46 (Google Scholar).
RESEARCH FIELDS: Structural biology; Metalloproteins; Bioinformatics; Bioinorganic chemistry; Computational biology; distributed computing
SELECTED PUBLICATIONS: Sala D, Cerofolini L, Fragai M, Giachetti A, Luchinat C, Rosato A A protocol to automatically calculate homo-oligomeric protein structures through the integration of evolutionary constraints and NMR ambiguous contacts Computational and structural biotechnology journal 18, 114-124, 2020. Sala D, [...] Rosato A, Montelione GT Protein structure prediction assisted with sparse NMR data in CASP13. Proteins. 87:1315-1332, 2019 Putignano V, Rosato A, Banci L, Andreini C. MetalPDB in 2018: a database of metal sites in biological macromolecular structures Nucleic Acids Res. 46(D1):D459-D464, 2018. Sala D, Ciambellotti S, Giachetti A, Turano P, Rosato A Investigation of the iron (II) release mechanism of human H-ferritin as a function of pH. J Chem Inf Model. 57:2112-2118, 2017. Rosato A, et al. Blind testing of routine, fully automated determination of protein structures from NMR data. Structure. 20:227-236, 2012
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